Motif ID: NANOG{mouse}.p2

Z-value: 0.748


Transcription factors associated with NANOG{mouse}.p2:

Gene SymbolEntrez IDGene Name
NANOG 79923 Nanog homeobox

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
NANOGchr12_+_78332920.421.1e-01Click!


Activity profile for motif NANOG{mouse}.p2.

activity profile for motif NANOG{mouse}.p2


Sorted Z-values histogram for motif NANOG{mouse}.p2

Sorted Z-values for motif NANOG{mouse}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NANOG{mouse}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_143523582 1.568 NM_001003702
ARHGEF35
Rho guanine nucleotide exchange factor (GEF) 35
chr14_-_91268136 1.330 NM_024764
CATSPERB
cation channel, sperm-associated, beta
chr10_+_129735796 1.274 NM_130435
PTPRE
protein tyrosine phosphatase, receptor type, E
chr1_-_246857051 1.222 NM_001001964
OR2T11
olfactory receptor, family 2, subfamily T, member 11
chrX_+_133952633 1.182 NM_001163438
LOC644538
hypothetical protein LOC644538
chr7_+_143683365 1.126 NM_005435
ARHGEF5
Rho guanine nucleotide exchange factor (GEF) 5
chr7_-_143622188 1.118 ARHGEF5
Rho guanine nucleotide exchange factor (GEF) 5
chr10_+_102881050 1.050 NM_001195517
NM_005521
TLX1

T-cell leukemia homeobox 1

chr10_-_48010879 1.036 NM_002900
RBP3
retinol binding protein 3, interstitial
chr12_-_83830710 1.020 NM_001146335
NM_018057
NM_182767
SLC6A15


solute carrier family 6 (neutral amino acid transporter), member 15


chr12_-_121753795 1.017 NM_177551
GPR109A
G protein-coupled receptor 109A
chr11_+_117452936 0.981 NM_001083947
NM_001173551
NM_001173552
NM_019894
TMPRSS4



transmembrane protease, serine 4



chr2_+_84597087 0.945 NM_001370
DNAH6
dynein, axonemal, heavy chain 6
chr11_-_56137553 0.867 NM_001004740
OR5M1
olfactory receptor, family 5, subfamily M, member 1
chr20_-_21442663 0.811 NM_002509
NKX2-2
NK2 homeobox 2
chr1_+_47037256 0.807 NM_000779
NM_001099772
CYP4B1

cytochrome P450, family 4, subfamily B, polypeptide 1

chr7_-_143622233 0.753 ARHGEF35
Rho guanine nucleotide exchange factor (GEF) 35
chr19_-_60557875 0.742 NM_144613
COX6B2
cytochrome c oxidase subunit VIb polypeptide 2 (testis)
chr7_+_121300394 0.717 NM_002851
PTPRZ1
protein tyrosine phosphatase, receptor-type, Z polypeptide 1
chr19_-_59019240 0.683 NM_144687
NLRP12
NLR family, pyrin domain containing 12
chr10_+_5556923 0.668 NM_005185
CALML3
calmodulin-like 3
chr12_+_117903682 0.657 NM_194286
SRRM4
serine/arginine repetitive matrix 4
chr22_-_28992787 0.654 NM_020530
OSM
oncostatin M
chr11_+_34599163 0.650 NM_012153
EHF
ets homologous factor
chr4_-_153820535 0.650 NM_152680
TMEM154
transmembrane protein 154
chr1_+_208472817 0.646 NM_019605
SERTAD4
SERTA domain containing 4
chr16_+_580092 0.628 RAB40C
RAB40C, member RAS oncogene family
chr7_+_121300446 0.618 PTPRZ1
protein tyrosine phosphatase, receptor-type, Z polypeptide 1
chr17_-_7138620 0.606 YBX2
Y box binding protein 2
chr1_+_43508251 0.600 NM_144626
TMEM125
transmembrane protein 125
chrX_+_17563333 0.593 NM_001136024
NHS
Nance-Horan syndrome (congenital cataracts and dental anomalies)
chr9_+_134275431 0.592 NM_207417
C9orf171
chromosome 9 open reading frame 171
chr17_-_36528113 0.585 NM_033059
KRTAP4-11
keratin associated protein 4-11
chr16_+_580057 0.570 NM_001172665
NM_001172666
RAB40C

RAB40C, member RAS oncogene family

chr1_+_159817752 0.568 NM_201563
FCGR2C
Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr13_+_57103944 0.553 PCDH17
protocadherin 17
chr12_-_121780835 0.552 NM_032554
GPR81
G protein-coupled receptor 81
chr7_+_150013716 0.548 NM_015660
GIMAP2
GTPase, IMAP family member 2
chr10_+_63803921 0.539 NM_014951
NM_199450
NM_199451
ZNF365


zinc finger protein 365


chr22_+_43527101 0.534 NM_001017526
NM_001198726
NM_181335
ARHGAP8


Rho GTPase activating protein 8


chrX_-_119908413 0.528 NM_173571
NM_001080137
NM_001080138
NM_001080139
NM_001080141
NM_001080142
NM_001080143
NM_001080144
NM_001080145
NM_001080146
CT47A11
CT47A10
CT47A9
CT47A8
CT47A6
CT47A5
CT47A4
CT47A3
CT47A2
CT47A1
cancer/testis antigen family 47, member A11
cancer/testis antigen family 47, member A10
cancer/testis antigen family 47, member A9
cancer/testis antigen family 47, member A8
cancer/testis antigen family 47, member A6
cancer/testis antigen family 47, member A5
cancer/testis antigen family 47, member A4
cancer/testis antigen family 47, member A3
cancer/testis antigen family 47, member A2
cancer/testis antigen family 47, member A1
chr2_+_64535114 0.525 HSPC159
galectin-related protein
chrX_+_85290117 0.523 DACH2
dachshund homolog 2 (Drosophila)
chrX_+_85290106 0.514 NM_001139514
NM_053281
DACH2

dachshund homolog 2 (Drosophila)

chr10_+_85994788 0.512 NM_001012720
NM_001012722
NM_002921
RGR


retinal G protein coupled receptor


chr14_+_75907442 0.509 NM_004452
ESRRB
estrogen-related receptor beta
chr8_+_22188754 0.509 NM_018068
PIWIL2
piwi-like 2 (Drosophila)
chr1_+_159899528 0.507 NM_001002273
NM_001002274
NM_001002275
NM_001190828
NM_004001
FCGR2B




FCGR2C
Fc fragment of IgG, low affinity IIb, receptor (CD32)




Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chr2_+_113591940 0.499 NM_000577
NM_173841
NM_173843
IL1RN


interleukin 1 receptor antagonist


chrX_-_48713194 0.497 NM_004979
KCND1
potassium voltage-gated channel, Shal-related subfamily, member 1
chr7_-_75876830 0.490 NM_080744
SRCRB4D
scavenger receptor cysteine rich domain containing, group B (4 domains)
chr10_-_134449467 0.489 NM_177400
NKX6-2
NK6 homeobox 2
chr16_-_3025542 0.484 NM_001103175
CCDC64B
coiled-coil domain containing 64B
chr17_+_7846636 0.481 NM_000180
GUCY2D
guanylate cyclase 2D, membrane (retina-specific)
chr19_+_54776398 0.473 NM_000951
PRRG2
proline rich Gla (G-carboxyglutamic acid) 2
chr5_-_50714836 0.469 LOC642366
hypothetical LOC642366
chr16_+_579669 0.468 NM_001172664
RAB40C
RAB40C, member RAS oncogene family
chr20_+_42777419 0.460 WISP2
WNT1 inducible signaling pathway protein 2
chr5_+_140200995 0.456 NM_018911
NM_031856
PCDHA8

protocadherin alpha 8

chr20_+_36408237 0.451 NM_004139
LBP
lipopolysaccharide binding protein
chr11_-_72182291 0.447 NM_006645
STARD10
StAR-related lipid transfer (START) domain containing 10
chr8_-_143482433 0.440 NM_145003
TSNARE1
t-SNARE domain containing 1
chr17_-_59131194 0.439 LIMD2
LIM domain containing 2
chr1_+_20338405 0.439 NM_022819
PLA2G2F
phospholipase A2, group IIF
chr20_+_42777298 0.430 NM_003881
WISP2
WNT1 inducible signaling pathway protein 2
chr1_-_28392966 0.420 NM_001164722
NM_001164721
PTAFR

platelet-activating factor receptor

chr10_-_73167586 0.420 NM_001168390
C10orf105
chromosome 10 open reading frame 105
chr13_+_99056887 0.420 NM_206808
CLYBL
citrate lyase beta like
chr11_+_2378559 0.412 TSSC4
tumor suppressing subtransferable candidate 4
chr12_+_10222823 0.402 NM_153022
C12orf59
chromosome 12 open reading frame 59
chr2_+_68815416 0.399 NM_001007231
NM_001166277
ARHGAP25

Rho GTPase activating protein 25

chr20_+_55718718 0.395


chr11_-_34491878 0.394 NM_001422
ELF5
E74-like factor 5 (ets domain transcription factor)
chr3_-_152517204 0.392 NM_023915
GPR87
G protein-coupled receptor 87
chr10_-_102880892 0.388 NM_001085398
TLX1NB
TLX1 neighbor
chr20_+_42776888 0.384 WISP2
WNT1 inducible signaling pathway protein 2
chr1_-_145712107 0.378 NM_005266
GJA5
gap junction protein, alpha 5, 40kDa
chr5_+_50714996 0.375 ISL1
ISL LIM homeobox 1
chr5_-_39400319 0.374 NM_001737
C9
complement component 9
chr14_-_90596665 0.373 NM_004755
NM_182398
RPS6KA5

ribosomal protein S6 kinase, 90kDa, polypeptide 5

chr3_+_52543023 0.369


chr11_+_34599227 0.368 EHF
ets homologous factor
chr14_-_98807307 0.368 BCL11B
B-cell CLL/lymphoma 11B (zinc finger protein)
chr9_-_72673753 0.365 NM_001007470
NM_020952
NM_024971
NM_206944
NM_206945
NM_206946
NM_206947
NM_206948
TRPM3







transient receptor potential cation channel, subfamily M, member 3







chr22_+_24895454 0.364 SEZ6L
seizure related 6 homolog (mouse)-like
chr9_+_137119334 0.362 OLFM1
olfactomedin 1
chr11_-_6773589 0.361 NM_003696
OR6A2
olfactory receptor, family 6, subfamily A, member 2
chr5_+_169749068 0.360


chr6_+_31647854 0.359 NM_001159740
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chr12_-_121767272 0.358 NM_006018
GPR109B
G protein-coupled receptor 109B
chr20_+_55718619 0.356


chr22_-_22426551 0.351 NM_013378
VPREB3
pre-B lymphocyte 3
chr3_-_135852514 0.350 NM_178554
KY
kyphoscoliosis peptidase
chr6_-_31740645 0.344 NM_033177
GPANK1
G patch domain and ankyrin repeats 1
chr3_-_140741167 0.344 RBP1
retinol binding protein 1, cellular
chr15_+_38923470 0.335 NM_003710
NM_181642
SPINT1

serine peptidase inhibitor, Kunitz type 1

chr2_-_198358253 0.332 NM_033030
BOLL
bol, boule-like (Drosophila)
chr11_+_129445136 0.331


chr20_-_57942063 0.330 SYCP2
synaptonemal complex protein 2
chr14_-_98807574 0.329 NM_022898
NM_138576
BCL11B

B-cell CLL/lymphoma 11B (zinc finger protein)

chr7_+_150180510 0.328 ABP1
amiloride binding protein 1 (amine oxidase (copper-containing))
chr15_-_29734833 0.324 NM_130901
OTUD7A
OTU domain containing 7A
chr19_+_15058790 0.320 NM_001004713
OR1I1
olfactory receptor, family 1, subfamily I, member 1
chr22_+_35777561 0.318 NM_024681
KCTD17
potassium channel tetramerisation domain containing 17
chr8_-_144583718 0.316 NM_201589
MAFA
v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)
chr7_-_82630063 0.313 NM_014510
NM_033026
PCLO

piccolo (presynaptic cytomatrix protein)

chr11_-_69228286 0.310 NM_005117
FGF19
fibroblast growth factor 19
chr10_-_69125932 0.308 NM_013266
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr8_-_71146103 0.308 NM_024504
PRDM14
PR domain containing 14
chr6_-_27949266 0.306 NM_003546
HIST1H4L
histone cluster 1, H4l
chr16_+_6009095 0.306 NM_001142333
NM_018723
RBFOX1

RNA binding protein, fox-1 homolog (C. elegans) 1

chr7_+_150180464 0.305 NM_001091
ABP1
amiloride binding protein 1 (amine oxidase (copper-containing))
chr9_+_33667169 0.303


chr2_-_133256097 0.303 NCKAP5
NCK-associated protein 5
chr6_-_31741369 0.300 GPANK1
G patch domain and ankyrin repeats 1
chr14_+_20580224 0.299 NM_032572
RNASE7
ribonuclease, RNase A family, 7
chr1_-_47468029 0.298 NM_003189
TAL1
T-cell acute lymphocytic leukemia 1
chr1_-_153560532 0.298 NM_001039517
C1orf104
chromosome 1 open reading frame 104
chr14_+_28306633 0.297 FOXG1
forkhead box G1
chr8_+_22189024 0.296 NM_001135721
PIWIL2
piwi-like 2 (Drosophila)
chr11_+_6854431 0.293 NM_207186
OR10A4
olfactory receptor, family 10, subfamily A, member 4
chr16_+_580173 0.293 NM_021168
RAB40C
RAB40C, member RAS oncogene family
chr19_-_2998632 0.292 NM_001144761
TLE2
transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)
chr2_-_142605010 0.291 LRP1B
low density lipoprotein receptor-related protein 1B
chr18_+_13208777 0.289 NM_181481
NM_181482
C18orf1

chromosome 18 open reading frame 1

chr11_-_66245288 0.284 NM_006946
SPTBN2
spectrin, beta, non-erythrocytic 2
chr1_-_2451543 0.283 NM_001010926
HES5
hairy and enhancer of split 5 (Drosophila)
chrX_+_14457340 0.281 NM_001118885
NM_001118886
NM_001171942
NM_002063
GLRA2



glycine receptor, alpha 2



chr11_+_1897374 0.280 NM_001042780
NM_001042781
NM_001042782
NM_006757
TNNT3



troponin T type 3 (skeletal, fast)



chr1_+_175406685 0.278 FAM5B
family with sequence similarity 5, member B
chr6_-_32268267 0.278 GPSM3
G-protein signaling modulator 3
chr9_-_106401514 0.274 NM_001004482
OR13C5
olfactory receptor, family 13, subfamily C, member 5
chr19_-_13074513 0.273 LYL1
lymphoblastic leukemia derived sequence 1
chr12_-_55637648 0.271 NM_003708
RDH16
retinol dehydrogenase 16 (all-trans)
chr22_+_24895424 0.271 NM_001184773
NM_001184774
NM_001184775
NM_001184776
NM_001184777
NM_021115
SEZ6L





seizure related 6 homolog (mouse)-like





chrX_+_103243762 0.268 NM_001143978
ZCCHC18
zinc finger, CCHC domain containing 18
chr3_+_44891101 0.265 NM_003241
TGM4
transglutaminase 4 (prostate)
chrX_-_107569256 0.264 NM_001847
COL4A6
collagen, type IV, alpha 6
chr9_-_125070675 0.263 NM_001171137
STRBP
spermatid perinuclear RNA binding protein
chr1_-_221919982 0.260 CAPN8
calpain 8
chr3_-_42427026 0.258 NM_144634
LYZL4
lysozyme-like 4
chr16_+_79132354 0.255 NM_130897
DYNLRB2
dynein, light chain, roadblock-type 2
chr3_-_58627509 0.254 NM_138805
FAM3D
family with sequence similarity 3, member D
chr14_+_94097513 0.252 NM_006215
SERPINA4
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
chr7_-_143587653 0.251 NM_001005328
OR2A7
OR2A4
olfactory receptor, family 2, subfamily A, member 7
olfactory receptor, family 2, subfamily A, member 4
chr16_-_54547443 0.249 NM_001190158
CES5A
carboxylesterase 5A
chr6_-_33494042 0.241 NM_001014433
NM_001014837
NM_001014838
NM_001014840
NM_015921
CUTA




cutA divalent cation tolerance homolog (E. coli)




chrX_-_103060777 0.240 LOC100128594
hypothetical LOC100128594
chr20_-_55718351 0.240 NM_020182
PMEPA1
prostate transmembrane protein, androgen induced 1
chr12_+_88626770 0.240 LOC338758
hypothetical LOC338758
chr3_+_130744746 0.236 NM_153833
H1FOO
H1 histone family, member O, oocyte-specific
chr5_+_161210280 0.234 NM_001127648
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr11_+_48194937 0.232 NM_001005470
OR4B1
olfactory receptor, family 4, subfamily B, member 1
chr2_+_220145197 0.230 NM_002191
INHA
inhibin, alpha
chr17_-_7328237 0.230 NM_020899
ZBTB4
zinc finger and BTB domain containing 4
chr15_+_42368227 0.230 CASC4
cancer susceptibility candidate 4
chr11_-_123799976 0.228 NM_001005196
OR8B4
olfactory receptor, family 8, subfamily B, member 4
chrX_-_15782803 0.227 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr3_+_122769467 0.227 NM_001012659
ARGFX
arginine-fifty homeobox
chr3_-_59010777 0.227 C3orf67
chromosome 3 open reading frame 67
chr20_-_3710060 0.226 NM_015417
SPEF1
sperm flagellar 1
chr17_-_10265991 0.226 NM_002472
MYH8
myosin, heavy chain 8, skeletal muscle, perinatal
chr7_-_26206845 0.226 HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
chr11_+_63498590 0.226 NM_004074
COX8A
cytochrome c oxidase subunit VIIIA (ubiquitous)
chr10_-_6144119 0.225 NM_000417
IL2RA
interleukin 2 receptor, alpha
chr2_-_21084077 0.224 APOB
apolipoprotein B (including Ag(x) antigen)
chrX_-_119893806 0.222 NM_001145718
CT47B1
cancer/testis antigen family 147, member B1
chr9_+_137119339 0.220 OLFM1
olfactomedin 1
chr9_-_4656665 0.220 NM_001039395
C9orf68
chromosome 9 open reading frame 68
chr15_-_48345453 0.219 NM_002112
HDC
histidine decarboxylase
chr6_-_47117951 0.215 NM_025048
NM_153840
GPR110

G protein-coupled receptor 110

chr17_-_7138590 0.214 NM_015982
YBX2
Y box binding protein 2
chr3_-_140741063 0.212 RBP1
retinol binding protein 1, cellular
chr4_+_37131946 0.212 NM_001104629
C4orf19
chromosome 4 open reading frame 19
chr3_-_46761248 0.211 NM_199183
PRSS45
protease, serine, 45
chr19_+_3129735 0.211 NM_003775
S1PR4
sphingosine-1-phosphate receptor 4
chr17_+_4283967 0.211 NM_182538
SPNS3
spinster homolog 3 (Drosophila)
chr7_+_143646150 0.209 NM_001005287
NM_001001802
OR2A1
OR2A42
olfactory receptor, family 2, subfamily A, member 1
olfactory receptor, family 2, subfamily A, member 42
chr10_-_17211795 0.208 NM_001081
CUBN
cubilin (intrinsic factor-cobalamin receptor)
chr10_+_80942362 0.208 NM_001099692
EIF5AL1
eukaryotic translation initiation factor 5A-like 1
chr10_-_123347493 0.206 NM_000141
NM_001144917
NM_001144918
NM_001144919
NM_022970
FGFR2




fibroblast growth factor receptor 2




chr14_-_44046202 0.206 NM_032135
FSCB
fibrous sheath CABYR binding protein
chr1_-_221920023 0.204 NM_001143962
CAPN8
calpain 8
chr4_-_103485419 0.204 NM_001135147
SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr15_+_88120592 0.202 NM_001039958
MESP2
mesoderm posterior 2 homolog (mouse)
chr14_-_56342097 0.200 NM_172337
OTX2
orthodenticle homeobox 2
chr9_-_125070613 0.199 NM_018387
STRBP
spermatid perinuclear RNA binding protein
chr6_-_26164478 0.199 NM_005319
HIST1H1C
histone cluster 1, H1c
chrX_-_133620103 0.198 NM_021796
PLAC1
placenta-specific 1
chr3_-_198784590 0.193 NM_203315
BDH1
3-hydroxybutyrate dehydrogenase, type 1
chr11_-_56761250 0.193 NM_005161
APLNR
apelin receptor
chr3_+_185232223 0.192 NM_001145143
HTR3D
5-hydroxytryptamine (serotonin) receptor 3 family member D
chr6_+_31648071 0.192 NM_000595
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chr12_-_56447090 0.192 NM_000785
CYP27B1
cytochrome P450, family 27, subfamily B, polypeptide 1
chr2_-_21084911 0.192 APOB
apolipoprotein B (including Ag(x) antigen)
chr11_+_59806661 0.191 NM_024021
MS4A4A
membrane-spanning 4-domains, subfamily A, member 4
chr1_-_246880807 0.188 NM_001001824
OR2T27
olfactory receptor, family 2, subfamily T, member 27
chr12_+_7348194 0.187 NM_001080454
ACSM4
acyl-CoA synthetase medium-chain family member 4
chr6_-_32206029 0.187 NM_022110
FKBPL
FK506 binding protein like
chr2_+_108271526 0.185 NM_001056
NM_176825
SULT1C2

sulfotransferase family, cytosolic, 1C, member 2


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.26 3.99e-02 GO:0032501 multicellular organismal process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.36 7.62e-05 GO:0071944 cell periphery
1.36 1.52e-04 GO:0005886 plasma membrane
1.26 1.89e-03 GO:0016021 integral to membrane
1.25 2.91e-03 GO:0031224 intrinsic to membrane
1.22 7.25e-03 GO:0044425 membrane part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.78 4.35e-07 GO:0004872 receptor activity
1.88 2.19e-06 GO:0004888 transmembrane receptor activity
1.65 2.97e-06 GO:0004871 signal transducer activity
1.65 2.97e-06 GO:0060089 molecular transducer activity
1.95 2.00e-04 GO:0004930 G-protein coupled receptor activity
2.09 4.01e-02 GO:0004984 olfactory receptor activity